The book, according to Joseph Fitzmyer, "overwhelms the reader by the density and sublimity of the topic with which it deals, the gospel of the justification and salvation of Jew and Greek alike by the grace of God through faith in Jesus Christ, revealing the uprightness and love of God the father." N.T. Wright notes that Romans is "neither a systematic theology nor a summary of Paul's lifework, but it is by common consent his masterpiece.
Paul's Epistle to the Romans dwarfs most of his other writings, an Alpine peak towering over hills and villages. Not all onlookers have viewed it in the same light or from the same angle, and their snapshots and paintings of it are sometimes remarkably unalike. Not all climbers have taken the same route up its sheer sides, and there is frequent disagreement on the best approach. What nobody doubts is that we are here dealing with a work of massive substance, presenting a formidable intellectual challenge while offering a breathtaking theological and spiritual vision".
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