Founded near the end of the 4th century BC by Seleucus I Nicator, one of Alexander the Great's generals, Antioch was destined to rival Alexandria as the chief city of the nearer East and to be the cradle of gentile Christianity.
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The geographical character of the district north and north-east of the elbow of Orontes makes it the natural centre of Syria, so long as that country is held by a western power; and only Asiatic, and especially Arab, dynasties have neglected it for the oasis of Damascus.
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